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The antioxidant xCT/GPX4 signaling pathway has been demonstrated to be implicated in ferroptosis, where xCT protects cells from oxidative stress by importing cystine and reducing it to cysteine for GSH synthesis 24

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This is consistent with the notion that gpx-3(tm2059), gpx-5(tm2024) and gpx-8(tm2108) mutants have a moderate level of lipid oxidation and that either enhancing or reducing the level disrupts axonal fusion

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This can be life-threatening because it can stop blood from reaching parts of the lung