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Furthermore, by securing their metabolic resilience against ferroptosis, DJ-1-competent astrocytes can better provide trophic support, regulate extracellular glutamate, and mitigate neuroinflammatory cascades, all processes that indirectly influence neuronal susceptibility to ferroptotic death (Cao et al., 2020)

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Where they overlap: both modulate neuroinflammation and support neuroplasticity, but through different mechanisms

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Regulation of ferroptosis by PI3K/Akt signaling pathway: a promising therapeutic axis in cancer