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GLP-1R Pathway Research All three compounds activate GLP-1R

On its own, phentermine produces modest weight loss of 3-5% of body weight

The underlying mechanism is not fully understood, but it's theorized that these drugs may alter pancreatic enzyme levels or cause changes in ductal cells, leading to pancreatitis in susceptible individuals

We can challenge the physicians who are doing the prescribing. The drugmaker sent cease-and-desist letters to telehealth companies, wellness centers, and medical spas last August to stop the promotion of the compounded versions of Zepbound and Mounjaro