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Prior investigations discovered an inverse relationship between TMAO and glomerular filtration rate in individuals with CKD and established a connection between elevated levels of TMAO and tubulointerstitial fibrosis, suggesting an unfavorable prognosis for CKD patients (72, 73)

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The patients with CVD received a simplified OCCT by urine sampling and were categorized according to urine OCCT TMAO MAX level (uOCCT TMAO MAX )

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