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If you are consistently eating well below your calculated target without trying, you may be in too deep a deficit

Without clinical trial data, that question remains unanswered

Baseline body mass index (BMI) and metabolic health: Patients with higher baseline BMI often experience greater absolute weight loss, though percentage reductions may be similar across BMI categories

Patients should be counseled that long-term or indefinite treatment may be necessary to maintain weight loss, and this does not indicate medication failure but rather appropriate management of a chronic condition

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