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Each hour outside the refrigerator reduces potency

Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) and dual GLP-1/gastric inhibitory polypeptide (GIP) receptor agonists (GLP-based therapies) are newer pharmacologic therapies that are used for management of hyperglycemia in type 2 diabetes and are approved for weight loss purposes in the absence of underlying diabetes

10.1038/nature01071 95 YaoT.XuW.DeMartinoG

In adipose tissue, HIF activation can improve IR by stimulating the thermogenic function of brown adipose tissue (BAT) by regulating mitochondrial biogenesis and glycolysis