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Key Takeaways Steroid Dependency Creates a Vicious Cycle - Perioral dermatitis can be worsened or induced by prolonged steroid use Stopping Wrong Treatments Is Key - Discontinuation of topical steroids combined with proper therapy leads to clearing Hidden Triggers Are Everywhere - Fluoride toothpaste and skincare products can trigger flares Oral Antibiotics Often Effective - Systemic antibiotics like tetracycline show better response than topical treatments alone Recovery Takes Time and Patience - Most cases improve with proper management over several weeks to months Table of Contents Understanding Perioral Dermatitis: More Than Just Red Bumps Look closely at where the rash appears

The study by Hendren et al

Autoantibodies and interferon- present in SLE sera enhance binding of the transcriptional repressor CREM to Gpx4 promoter, which leads to suppressed expression of GPX4 and subsequent elevation of lipid-ROS

437,438 Elevated serum levels of soluble intracellular adhesion molecule 1 (sICAM-1), indicative of increased vascular inflammation and/or endothelial dysfunction, have also been reported in PDPN

May 25, 2021