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These effects are likely mediated by Wnt/-catenin signaling, which is activated via increased -catenin, proven by Li et al

(49) found that lupeol may regulate TLR-4 and TLR-2 gene expression and serum TNF- levels in DHEA-induced PCOS mice, thereby reducing serum testosterone levels and treating hyperandrogenemia

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However, this discrepancy between our post-marketing findings and the phase 3 trial results underscores the importance of ongoing pharmacovigilance and real-world evidence studies in identifying rare but potentially serious adverse effects that may not be captured in pre-approval clinical trials

Actualmente en investigacin clnica avanzada para el control metablico