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In the initial stages of the disease, patients can also be referred to an optometrist to perform a slit lamp examination to determine the presence of KF rings

86 This was thought to occur via suppression of inhibitors of melanogenesis (IL17 and TNFa) that depend on IL23 upstream

Nevertheless, they represent a great advance in investigation technology and their attempt to biomimicking cell and tissue environment is a crucial advantage compared to 2D cultures and a promising complement to animal model studies with great potential for further investigation of ECD in the context of CVDs

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Requires good side-effect management