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In male Wistar rats experiencing transient ischemic stroke, UA suppresses the upregulation of cerebrocortical Vegfa expression in the acute phase of stroke and reduces the MMP-9/TIMP-1 ratio in the brain cortex, indicating that UA treatment may aid in the downregulation of the VEGF-A/MMP-9 pathway to improve BBB integrity [54]

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Equal and long-term access to treatment and cost-effectiveness One of the most challenging aspects of this new era in obesity management will be the long-term and equal access to the new obesity pharmacotherapies through funding from national health systems and/or private health insurances as there is lack of robust cost-effectiveness data

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