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Patients typically move to 5 mg, then 7.5 mg, 10 mg, 12.5 mg, and finally 15 mg as the maximum dose

HNE is generated from polyunsaturated fatty acids in biological membranes by a radical-based peroxidation chain reaction (Jacobs and Marnett, 2014)

Maintenance of this dynamic balance is mainly dependent on 3 elements: the structural integrity of the vascular wall and regulatory function of the vascular endothelium