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Taken together with the studies in knockout and transgenic GPx1 models, these findings suggest a role for GPx1 in the regulation of insulin and glucose metabolism and suggest that modulation of selenoprotein expression, including GPx1, may influence metabolism in humans, as well
This prevents receptor downregulation and maintains the system's sensitivity, which is absolutely crucial for long-term studies
10.1111/j.1471-4159.2006.03730.x J
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