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Lipid peroxidation during ferroptosis proceeds as follows: (1) the initial reaction occurs between ROS (e.g., hydroxyl radicals), that seem to be derived from NADPH oxidase rather than mitochondrial ETC, at least under some circumstances (Dixon et al., 2012), and hydrogen atoms in unsaturated lipids, typically polyunsaturated fatty acids (PUFAs)

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Chemosphere 65:699706 Speers-Roesch B, Ballantyne JS (2005) Activities of antioxidant enzymes and cytochrome c oxidase in liver of Arctic and temperate teleosts

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Several commenters requested that CMS provide additional clarification surrounding why the agency believes that this measure of overall productivity growth across the economy is an adequate proxy for service-level efficiency gains within the Medicare program and stated their belief that it is unreasonable to extrapolate changes in physician productivity from estimates of nonfarm business productivity across the entire economy