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The net result was a large decrease in the lactate/pyruvate in all brain regions that occurred after 15 months of age, reflecting an oxidative shift of the brain cytoplasmic [NAD + ]/[NADH] with aging (Ding et al., 2021), opposite to the reductive shift with aging found in C57BL/6J mouse brain

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[3] It is a ghrelin-receptor agonist it activates the growth hormone secretagogue receptor type 1a (GHSR-1a), the same receptor that endogenous ghrelin, the stomach-derived hunger hormone, binds

Experiments led by first author Claire Gao, Ph.D., a postdoctoral fellow at NIHs National Institute of General Medical Sciences (NIGMS), utilized a fluorescence imaging technique to explore semaglutide-induced intracellular activity in living brain tissue from mice