3.1.1 The role of Se in GD A large number of studies have now confirmed Se deficiency as a risk factor for GD in areas with adequate soil Se levels ( Based on the damage to thyroid cells caused by low Se level, researchers have raised the possibility that Se supplementation may be beneficial in GD and have conducted a series of clinical studies (30)
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Probiotic treatment increased the abundance of Firmicutes and decreased Bacteroidetes and also increased the level of metabolites such as threonic acid, conduritol b epoxide 1, and ascorbate and decreased the level of D-arabitol and elaidic acid compared to the control group [272]
