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IF contributes to the maintenance of the intestinal barrier during inflammation by increasing Allobaculum and Bifidobacterium

A deeper understanding of the molecular mechanisms involved in MTX-induced intestinal injury may help to explain a number of the drugs toxicities and develop multiple strategies to be investigated to ameliorate the harmful adverse effects of MTX

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It could indicate inadequate caloric intake, nutritional deficiencies, dehydration, or rarely, an underlying condition unmasked by the metabolic changes