AOD-9604 stimulates lipolysis, which is the breakdown of fat, and inhibits lipogenesis, the process that transforms non-fat food materials into body fat
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The preclinical data is extraordinarily promising, with rapid onset, high potency, neurogenesis induction, and a favorable safety profile in animal models
Constipation can be managed with increased fiber and hydration
The standard cagrilintide monotherapy titration follows this schedule: 0.25 mg weekly for weeks 1-4, then 0.5 mg for weeks 5-8, then 1.0 mg for weeks 9-12, then 1.7 mg for weeks 13-16, and finally 2.4 mg for week 17 onward as the maintenance dose