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Several studies finding evidence of increased levels of free radicals called isoprostanes suggest problems with the antioxidant system in ME/CFS are present

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These two intracellular signalling axes are complementary: cAMP/PKA primes the somatotroph for secretion while IP/calcium triggers the exocytotic event

In short, yes, but the key to creatine safety is following the recommended dosage and any advice you receive from your healthcare professional