Use of the arginine-depleting agent pegylated arginine deiminase ADI-PEG20 in GBM can increase nitric oxide (NO) synthesis and produce cytotoxic pernitrite, increasing the sensitivity of tumor cells to ionizing radiation and significantly enhancing the effect of radiotherapy on GBM
Stopping the drug usually causes weight regain
These region-specific KP responses likely contribute to distinct depressive symptoms: altered amygdala activity may underlie increased fear and anxiety, while changes in the hippocampus and prefrontal cortex may disrupt cognition and emotional regulation
I think its important to reach out to folks with empathy, to understand where theyre coming from. That includes figuring out what barriers people face when trying to access these medications
If you have developed any skin redness, avoid exercise, saunas, or hot showers until the redness or swelling has returned back to normal, usually within 12 hours