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2f is rate-limiting and no enzymesubstrate complexes accumulate in contrast to enzymes with typical MichaelisMenten kinetics 2,39,52

Studies suggest that various transporters facilitate this process, allowing for the maintenance of intracellular glutathione levels, which are crucial for detoxifying harmful substances and maintaining cellular health

The underlying mechanism has not been investigated fully yet, however, Pycnogenol s validated effects on blood circulation and endothelial health are good explanations for its beneficial effects on symptoms like hot flashes and sexual behavior

doi: 10.4103/1319-3767.65201 33

10.1155/2016/7296092 192 XuS.JiaP.FangY.JinJ.SunZ.ZhouW.et al (2022)