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Once-Weekly Semaglutide with Lifestyle Intervention Results in Clinically Significant Weight Loss

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In the hypothalamus, liraglutide directly accessed the proopiomelanocortin/cocaine- and amphetamine-regulated transcript (POMC/CART) neurons expressing the GLP-1R, and appeared to be internalized, as expected when a GPCR ligand activates its receptor (117)

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