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It is also critical to include a solvent control in the experimental design, which does not mean a group treated with DMSO alone but an APAP + DMSO group

This is a conceptual argument rather than a measured one again, the human PK data do not exist but it illustrates why systemic delivery is not self-evidently advantageous for a cosmetic goal, and why the burden of proof sits squarely on anyone claiming injection is the better skin route

These findings underscore the intricate involvement of AKR1C3 in radiotherapy resistance across different cancer types, emphasizing its significance as a potential therapeutic target

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