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Patientcentered considerations Eligibility and benefit must be weighed against individual comorbidities, preferences, and treatment burden

2 The main reported adverse events associated with semaglutide were gastrointestinal including nausea, vomiting, diarrhea, abdominal pain, and constipation

Confocal microscopy Confocal images were acquired using a Leica TCS-SP2 confocal laser scanning unit equipped with argon and helium-neon laser beams and attached to a Leica DM1RB inverted microscope ( Leica Microsystems, Mannheim, Germany)

The outcomes were liver biopsy-based (NAFLD activity score [NAS], fibrosis stage, and NASH resolution), noninvasive technique-based (liver fat content on proton magnetic resonance spectroscopy [ 1 H-MRS] and controlled attenuation parameter [CAP]), biological, and anthropometric indicators

Arrange collection or return via your local council's clinical waste service or as directed by your local NHS trust never dispose of sharps in household waste