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Additionally, antidromic axon reflexes could trigger additional CGRP release in the dura (33)

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J Biol Chem 278:2393023935 Dubey AK, Kumar N, Sahu N, Verma PK, Ranjan R, Chakrabarty D, Behera SK, Mallick S (2016) Response of two rice cultivars differing in their sensitivity towards arsenic, differs in their expression of glutaredoxin and glutathione S-transferase genes and antioxidant usage

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If personnel take pyridostigmine in advance of exposure, soman will be prevented from binding to a significant percentage of available synaptic AChE because the AChE binding sites will be transiently occupied by pyridostigmine, and so irreversible soman aging (formation of a covalent bond) to the enzyme cannot take place