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The xCT inhibitor erastin also directly binds the mitochondrial voltage-dependent anion channels VDAC2 and VDAC3, thereby slowing down the oxidation of NADH and altering the membrane permeability, which results in mitochondrial dysfunction and oxidant release [111]

In Summary In conclusion, this article has shed light on the harmful effects of toxins on metabolic pathways, leading to undermethylation and copper overload, which can ultimately lead to mood disorders and depression

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Monoclonal antibodies provide a powerful approach to counteract hepatokine overexpression