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A novel target for next-generation obesity medications is nicotinamide N-methyltransferase (NNMT) 7,8,9,10,11 , an enzyme central to cellular metabolism and energy homeostasis 12

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In fact, SLU-PP-332 and 5-Amino-1MQ both preserve or build lean mass

The synthetic version, TB-500, replicates the active region of the larger protein