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Renal function is a primary determinant

2008;198(3):336.e15

Quercetin, coenzyme Q10, and L-canavanine as protective agents against lipid peroxidation and nitric oxide generation in endotoxin-induced shock in rat brain

The Importance of Consistent, Moderate Dosing When it comes to glutathione, the goal is to maintain a steady level of the antioxidant in your system rather than attempting to "shock" your body with high doses