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At 10 nmol/l Ex-4 inhibits IB-phosphorylation and prevents NF-B/p65 nuclear translocation, halving tumor necrosis factor alpha (TNF-) and IL-6 both intracellularly and in the medium [19], thereby attenuating pro-inflammatory signaling and enhancing hMSC viability under inflammatory conditions

These prebiotics reshape the profile of circulating inflammatory mediators, leading to a significant reduction in pro-inflammatory cytokinesincluding TNF-, IL-6, IL-8, and IL-1within both plasma and BALF 176

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