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mitochondrial NADP+-dependent isocitrate dehydrogenase (IDPm)

Rather than targeting a single receptor, MT2 binds to MC-1R (involved in pigmentation signaling), MC-4R (involved in glucose metabolism, cholesterol, and sexual behavior), and MC-3R (involved in appetite control)

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doi: 10.1016/j.smhs.2019.08.003

If you have a brain tumor related to using the Depo shot, you may be eligible for compensation from a Depo-Provera meningioma lawsuit