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Up to 4050% of the weight loss from GLP-1 drugs like tirzepatide or semaglutide may come from muscle and bone, increasing frailty risk when BMI is low

A decrease of the butyrate-producing species roseburia hominis and faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis

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As a GLP-1 receptor agonist, it closely mimics the functions of the naturally occurring gut hormone GLP-1, which is integral to glucose metabolism and appetite regulation

Mol Metab (2021) 46:101139