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Furthermore, geographic location, baseline selenium levels, habitual iodine intake, and disease stage may all affect an individuals reaction to supplementation [2,29,33,35,39]

doi: 10.2337/dc12-2709 78 HuntBKraghNMcConnachieCCValentineWJRossiMCMontagnoliR

Its Innovative Science and Technology Approaches for New Drugs (ISTAND) pilot program is explicitly considering complex in vitro models like OoCs, with a liver-on-chip for DILI being the first OoC accepted into the program for evaluation (222)

For example, coenzyme Q10 (CoQ10) is a fat-soluble dietary supplement that is best absorbed with high-fat meals

GG: Writing review & editing