In this study, the average time period after diagnosis to the start of the trial was 6.4 years
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[20] Pernicious anemia may be present without a person experiencing symptoms at first, over time, feeling tired and weak, lightheadedness, dizziness, headaches, rapid or irregular heartbeat, breathlessness, glossitis (a sore red tongue), poor ability to exercise, low blood pressure, cold hands and feet, pale or yellow skin, easy bruising and bleeding, low-grade fevers, tremor, cold sensitivity, chest pain, upset stomach, nausea, loss of appetite, heartburn, weight loss, diarrhea, constipation, severe joint pain, feeling abnormal sensations including tingling or numbness to the fingers and toes ( pins and needles ), and tinnitus, may occur
The clinical experts advised that semaglutide would be combined with therapies that reduce cardiorenal risk, including combination with renin-angiotensin-aldosterone system (RAAS) inhibitors (angiotensin-converting enzyme [ACE] or angiotensin receptor blockers [ARB]) and SGLT2 inhibitor therapies as well as other standard of care to improve CV outcomes
