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DSIP acts on several systems: it modulates GABAergic and serotonergic pathways, promotes the natural programming of slow-wave (delta) sleep, and stabilizes circadian rhythms

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By week 4, many of these patients have moved from significant functional impairment from GI symptoms to largely resolved or substantially reduced symptom burden

Blood flow restriction training may enhance adaptation with lower mechanical loads, potentially valuable during early healing phases when full loading remains inappropriate