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Ali, who was also not involved in this review, noted that a problem affecting a lot of research in this area is that it comes out of smaller studies as double-blind controlled studies require a lot of time and monetary investment. Obesity is a multifactorial condition

Caught in the middle While the battle over diabetes and weight-loss drugs is unprecedented, the drug companies aren't exactly using a new playbook, says Feldman, the law professor at the University of California

This is where many researchers first experience what they describe as "real" appetite suppression, the kind where you genuinely forget to eat, where a meal that used to seem normal now feels impossibly large, where the idea of a snack between meals simply does not occur to you

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