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PratleyRETuttleKRRossingPRasmussenSPerkovicVNielsenOWet alEffects of semaglutide on heart failure outcomes in diabetes and chronic kidney disease in the FLOW trial

systematic review of 13 Table 1 GLP-1 receptor agonistspharmacokinetic properties and clinical characteristics Agent Half-life Dosing schedule Peak concentration Bioavailability Duration of gastric eects Semaglutide 7days (165184h) Once weekly 13days 89% May persist 12weeks Liraglutide 13h Once daily 812h 55% 2448h Exenatide IR 2.4h Twice daily 2.1h Variable 2448h Exenatide ER ~ 2weeks Once weekly Multiphasic Variable 12weeks Dulaglutide 5days Once weekly 24weeks Variable 12weeks Tirzepatide 5days Once weekly 45weeks Variable Potentially reduced Content courtesy of Springer Nature, terms of use apply

March 2020

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Practical strategies for managing nausea Nausea is the side effect most likely to derail a protocol