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Five unique GSTP1 -specific shRNA plasmids (clones TRCN0000083 773 , TRCN0000083 774 , TRCN0000083 775 , TRCN0000083 776 and TRCN0000083 777 ) and a negative control plasmid (empty vector control, SHC001) were purchased as glycerol stocks and plasmid DNA extracted using plasmid DNA maxi prep kits (Qiagen, Manchester, UK) according to the manufacturers instructions

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Avoid freeze/thaw cycles, which can degrade peptide structure

Melanotan-2 is a neuroendocrine-related research compound developed for research into circadian signaling and time-regulated biological processes

5 These agents may offer therapeutic value for select patients with psoriasis or HS, especially among those whose disease burden is influenced by metabolic factors