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Park JM, Lee DH, Kim DH

Tirzepatide versus insulin degludec once daily in patients with type 2 diabetes (SURPASS-5): A double-blind, randomized, phase 3 trial

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Unfortunately, PF-4840154 is a hERG K + channel inhibitor and it has the predicted adverse side effect to induce cardiac arrhythmia 22

In the SURMOUNT-1 trial, tirzepatide at 15 mg achieved a mean weight reduction of 20.9%, approximately 6 percentage points above semaglutide's best result in comparable populations