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However, severe fractures disrupting blood supply (displaced fractures, comminuted breaks) face healing challenges despite bone's inherent vascularity

This timepoint was pre-specified to maximize the number observable while allowing sufficient duration of follow-up to evaluate the treatment effect reliably

This comprehensive approach supports overall health while addressing weight management objectives.

The dual glucagon-GLP-1 co-agonist SAR425899 was administered to overweight or obese human subjects for 28 days, improving glucose control and resulting in a maximal weight loss of 5 kg [52,58]