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The ability of organs for decreasing the toxicity of ROS and maintaining the balance of oxidative state depends on the anti-oxidative enzymes such as superoxide dismutase (SOD), catalase, and glutathione peroxidase (GSH-Px) (5)

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Additionally, renal function tests (eGFR and serum creatinine) and HbA1c levels should be tracked to adjust dosing and monitor blood sugar levels effectively

they may be on the trunk or extremities Axillary or inguinal freckling: these are small caf-au-lait macules and have the same microscopic appearance