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FDA-Approved Weight Loss Medications Overview The FDA has approved several medications specifically for chronic weight management, but they vary dramatically in effectiveness

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Hepatic and Metabolic Effects Excess caloric intake and insulin resistance drive hepatic lipid accumulation, producing metabolic-associated steatotic liver disease (MASLD, formerly NAFLD K76.0)

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This multi-organ mechanism underlies efficacy across T2D, obesity, cardiovascular disease, and emerging indications (MASH, sleep apnea, neurodegeneration)