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Treatment of Male hypogonadism Hypogonadism is the improper functioning of reproductive organs, like testes in males and ovaries in females, which causes failure to produce sex hormones required for fertility
Mannervik B, Jensson H (1982) Binary combinations of four protein subunits with different catalytic specificities explain the relationship between six basic glutathione S-transferases in rat liver cytosol
Glucose Metabolism (Gys1, Gys2, Pfkfb1 Pfkfb2, Pfkfb3, Pfkfb4, Slc2a4 (Glut4))
Consistently, a complementary strategy showed that in aged mice, where IGF-I levels are decreased, cardiac overexpression of IGF-I significantly improved cardiomyocyte contractile function[283], attenuating oxidative stress-mediated protein damage, normalizing Ca 2+ homeostasis, reversing age-related alterations in the expression of pro-apoptotic proteins, and decreasing the apoptosis rate[284]