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Moreover, G49 increased Cpt1b gene expression and FAO and up-regulated lipolysis, thermogenic gene expression ( Ucp1, Ppargc1a, Sir2 ) and UCP1 protein levels in BA (Fig

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Interestingly, clinical trials reported to date on the effects of tirzepatide did include obese men and women, but results were not segregated by gender 47 , thus making it difficult to anticipate whether a sex dimorphism exist in GLP1/GIP responses