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For example: Endogenous GHRH has a half-life of ~515 minutes Native GLP-1 is broken down in under 2 minutes Thats why natural peptides are rarely used directly in therapeutics theyre too unstable

Pharm Pharmacol Commun 6(11):517520 Panda S, Kar A (2001) Inhibition of T3 production in levothyroxine-treated female mice by the root extract of Convolvulus pluricaulis

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A healthy gut microbiome maintains delicate balance