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In mice, administration of LPS induces an acute lung injury similar to clinical ARDS, with production of inflammatory cytokines, leukocyte infiltration in the lung, and pulmonary edema

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Proc Natl Acad Sci U S A 90:79157922 Aono M, Kubo A, Saji H, Tanaka K, Kondo N (1993) Enhanced tolerance to photooxidative stress of transgenic Nicotiana tabacum with high chloroplast glutathione reductase activity

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The ratio between these forms serves as an important indicator of cellular oxidative stress