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Kuera and Cifra specifically considered a number of possible detection mechanisms in their analysis to identify conditions under which the mitogenetic effect could be considered plausible [30]

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Notably, the RFN element was not found in front of all transport units encoding the presumed riboflavin transporter ( Riboflavin-Producing Strain Improvement Attempts to improve microbial riboflavin-producing strains were made by both metabolic and genetic engineering, which include the following: (1) random mutagenesis by chemical exposure and UV irradiation ( Improvement of the producer most often begins with random mutagenesis and routine screening for mutants by qualitative and quantitative determination of riboflavin (Table 2)