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Quercetin can block KHK activity and reduce the expression of genes involved in fructose metabolism [1]

2014 Jan 1;71(1):19-25

Such a shift in immune strategy is probably the result of physiological trade-offs, environmentally dependent (e.g., warmer sea water conditions) and phenotypically plastic, that occur within the limits of maintaining an optimal health-state and balancing the costs of achieving it (Sadd and Schmid-Hempel 2009