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This process is morphologically marked by small mitochondria with condensed membrane densities, and biochemically by iron overload and GSH depletion, leading to loss of antioxidant defense and irreversible oxidative damage ( 3.2 Key molecular drivers of ferroptosis Iron Overload: Excess intracellular ferrous iron (Fe 2+ ) catalyzes the Fenton reaction, producing hydroxyl radicals (OH) that initiate lipid peroxidation cascades

[1] [13] Nausea is the most commonly reported side effect during the first week of GLP-1 therapy, but several practical strategies can help minimise this symptom and improve tolerability

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Notably, our semi-quantitative RNAscope data were not subjected to statistical analysis as we were not comparing experimental groups

A hallmark metabolic alteration is the shift from efficient aerobic oxidation via oxidative phosphorylation toward less efficient anaerobic glycolysis