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The contrast agent used in some MRIs is gadolinium, which is a metal that enhances the MRI image.[ref] A 2025 study showed that the presence of oxalic acid causes a decomposition reaction with gadolinium contrast agents (Omniscan and Doterem) to form gadolinium oxalate nanoparticles

The binding of a metal (or a metal complex) to the riboswitch aptamer alters the folding of the RNA such that transcriptional stop and/or translational off signals are disrupted, thus leading to expression of the immediately adjacent gene (an on switch)

Inclusion criteria for eligibility were: age range 2040 years old (young adults) and 6085 years old (older adults), both inclusive

Hydroxocobalamin is generally considered safe and can be taken for a very long time