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Figure 5D), a statistically significant decreased tumor volume was observed in SEMA mice (Fig

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-MSH binding to MC1R results in the activation of adenylyl cyclase, increasing the intracellular levels of cAMP and subsequently upregulating TYR, tyrosinase related protein-1 (TRP-1) and tyrosinase related protein-2 (TRP-2) expression

Regulation of this constitutive activity, either through allosteric interactions with other proteins, regulation of receptor internalization and trafficking, or modulation of transcription and translation, became an important area of research