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They tend to occur more often in individuals experiencing rapid weight loss, lower body fat, or slower metabolic rates, but clinical trials suggest these effects are occasional rather than widespread

Mechanistic studies have revealed that altered expression of iron metabolism-related proteins (including GPX4, FTH1, TfR1, and HO-1), accumulation of lipid peroxidation products, and disruption of antioxidant defense systems (particularly the Nrf2/GPX4 pathway) are central to ferroptosis progression in cardiac tissue

Anaemia with Laugier-Hunziker Syndrome: a diagnostic dilemma

This matters most when something goes wrong

Midwest to the East Coast